J E Darnell

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

Christian Schindler, Xiuping Fu, T Improta et al. · Proceedings of the National Academy of Sciences · 1992 · 664 citations

Systems Biology, Signal Transduction, Developmental Biology +14

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

Curt M. Horvath, J E Darnell · Genes & Development · 1995 · 536 citations · Full text

Novel Dna-binding Domain, Amino Acids, Genetics +18

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

David T. Levy, Daniel S. Kessler, Richard Pine et al. · Genes & Development · 1989 · 487 citations · Full text

Immunology, Transcriptional Regulation, Signaling Pathway +16

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

Richard Pine, Thomas Decker, Daniel S. Kessler et al. · Molecular and Cellular Biology · 1990 · 331 citations

Alpha Interferon, Transcriptional Regulation, Signal Transduction +15

Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.

Sajjad A. Qureshi, M. Salditt-Georgieff, J E Darnell · Proceedings of the National Academy of Sciences · 1995 · 235 citations · Full text

Molecular Biology, Stat Family, Contact Dna +17