T Improta

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

Christian Schindler, Xiuping Fu, T Improta et al. · Proceedings of the National Academy of Sciences · 1992 · 664 citations

Systems Biology, Signal Transduction, Developmental Biology +14

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

Xiuping Fu, Christian Schindler, T Improta et al. · Proceedings of the National Academy of Sciences · 1992 · 533 citations

Transcriptional Regulation, Systems Biology, Developmental Biology +14

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

Mathias Müller, Carl Laxton, James Briscoe et al. · The EMBO Journal · 1993 · 414 citations · Full text

Central Role, Developmental Biology, Signal Transduction +10

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.

T Improta, Christian Schindler, Curt M. Horvath et al. · Proceedings of the National Academy of Sciences · 1994 · 150 citations · Full text

Transcriptional Regulation, Stat91 Protein, Signal Transduction +15

Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.

Lawrence M. Pfeffer, Barbara L. Eisenkraft, Nancy C. Reich et al. · Proceedings of the National Academy of Sciences · 1991 · 89 citations · Full text

Daudi Cells, Immunology, Interferon Alpha +18