ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-β bioavailability regulation

Carine Le Goff, Fanny Morice‐Picard, Nathalie Dagoneau, +14

Nature Genetics

Tissue DevelopmentAdamtsl2 MutationsDevelopmental GeneticsGeneticsMedicine +4

Mutations in the TGFβ Binding-Protein-Like Domain 5 of FBN1 Are Responsible for Acromicric and Geleophysic Dysplasias

Carine Le Goff, Clémentine Mahaut, Lauren W. Wang, +36

The American Journal of Human Genetics

FibrosisDevelopmental BiologySignal TransductionMendelian DisorderGeleophysic Dysplasias +6

ADAMTS10 Protein Interacts with Fibrillin-1 and Promotes Its Deposition in Extracellular Matrix of Cultured Fibroblasts

Wendy E. Kutz, Lauren W. Wang, Hannah L. Bader, +6

Journal of Biological Chemistry

Molecular BiologyCytoskeletonCellular PhysiologyBone Morphogenic ProteinFibroblast Growth Factor +16

ADAMTSL4, a Secreted Glycoprotein Widely Distributed in the Eye, Binds Fibrillin-1 Microfibrils and Accelerates Microfibril Biogenesis

Luís Alexandre Rassi Gabriel, Lauren W. Wang, Hannah L. Bader, +5

Investigative Ophthalmology & Visual Science

Punctin, a Novel ADAMTS-like Molecule, ADAMTSL-1, in Extracellular Matrix

Satoshi Hirohata, Lauren W. Wang, Masaru Miyagi, +5

Journal of Biological Chemistry

ADAMTS9 Is a Cell-Autonomously Acting, Anti-Angiogenic Metalloprotease Expressed by Microvascular Endothelial Cells

Bon-Hun Koo, David M. Coe, Laura J. Dixon, +6

American Journal Of Pathology

InflammationAngiogenesisCell-autonomously ActingAnti-angiogenic MetalloproteaseMetalloprotein +10

ADAMTS7B, the Full-length Product of the ADAMTS7 Gene, Is a Chondroitin Sulfate Proteoglycan Containing a Mucin Domain

Robert Somerville, Jean-Michel Longpré, Elizabeth D. Apel, +5

Journal of Biological Chemistry

Post-translational Modification of Thrombospondin Type-1 Repeats in ADAMTS-like 1/Punctin-1 by C-Mannosylation of Tryptophan

Lauren W. Wang, Christina Leonhard-Melief, Robert S. Haltiwanger, +1

Journal of Biological Chemistry

<i>Adamtsl2</i> deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia – a novel mouse model providing insights into geleophysic dysplasia

Dirk Hubmacher, Lauren W. Wang, Robert P. Mecham, +2

Disease Models & Mechanisms

Bronchial WallLung InflammationPathologyGeleophysic DysplasiaTissue Development +17

O-Fucosylation of Thrombospondin Type 1 Repeats in ADAMTS-like-1/Punctin-1 Regulates Secretion

Lauren W. Wang, Malgosia Dlugosz, Robert Somerville, +3

Journal of Biological Chemistry