Procollagen II Amino Propeptide Processing by ADAMTS-3

Russell J. Fernandes, Satoshi Hirohata, J. Michael Engle, +4

Journal of Biological Chemistry

ADAM-TS5, ADAM-TS6, and ADAM-TS7, Novel Members of a New Family of Zinc Metalloproteases

Tiina Hurskainen, Satoshi Hirohata, Michael F. Seldin, +1

Journal of Biological Chemistry

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

Kazuhiro Yamamoto, Hiroshi Okano, Wakako Miyagawa, +8

Matrix Biology

Human ChondrocytesPathologyCellular PhysiologyInflammationBone Morphogenic Protein +18

Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis

Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi, +7

Arthritis Research & Therapy

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells

Tomonori Tetsunaga, Keiichiro Nishida, Takayuki Furumatsu, +5

Osteoarthritis and Cartilage

MechanobiologyRunx-2 Transcriptional FactorMusculoskeletal ResearchDevelopmental BiologyBone Morphogenic Protein +8

Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

Y. Nasu, Keiichiro Nishida, Shinichi Miyazawa, +7

Osteoarthritis and Cartilage

Histone Deacetylase InhibitorImmunologyDermatologyPsoriatic ArthritisInflammatory Arthritis +15

Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.

Tadashi Komata, Yasuko Kondo, Takao Kanzawa, +12

PubMed

ApoptosisCell DeathApoptotic PathwayGene PromoterMalignant Glioma Cells +18

Impact of Olmesartan on Progression of Coronary Atherosclerosis

Atsushi Hirohata, Keizô Yamamoto, Toru Miyoshi, +15

Journal of the American College of Cardiology

Vascular DiseaseCoronary AtherosclerosisCardiovascular DiseaseMedicinePhysiology +4

Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas

Mehmet Gündüz, Hitoshi Nagatsuka, Kadir Demircan, +12

Gene

OncologyFrequent DeletionMedicinePathologyHead And Neck Cancer +7

A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene Promoter

Shoji Koga, Satoshi Hirohata, Yasuko Kondo, +5

Human Gene Therapy

EngineeringIn Vivo Gene TherapyTelomerase ActivityApoptosisMolecular Biology +16