Isabelle Lyothier

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 5:  Linkage of Fragments C₁_-₆ and C₇_-₂₄ and Finale

Stuart J. Mickel, Daniel Niederer, Robert Daeffler et al. · Organic Process Research & Development · 2003 · 142 citations

Pharmacy, Medicinal Chemistry, Oncology +13

Iridium‐Catalyzed Enantioselective Synthesis of Allylic Alcohols: Silanolates as Hydroxide Equivalents

Isabelle Lyothier, Christian Defieber, Erick M. Carreira · Angewandte Chemie International Edition · 2006 · 138 citations

Natural Sciences, Chemistry, Catalysis +8

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone:  A Potent, Orally Bioavailable Human CB₁/CB₂Dual Agonist with Antihyperalgesic Properties and Restricted Central Nervous System Penetration

Edward K. Dziadulewicz, Stuart Bevan, Christopher T. Brain et al. · Journal of Medicinal Chemistry · 2007 · 96 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

1,6-Asymmetric Induction in Boron-Mediated Aldol Reactions:  Application to a Practical Total Synthesis of (+)-Discodermolide

Ian Paterson, Óscar Delgado, Gordon J. Florence et al. · Organic Letters · 2002 · 76 citations

Pharmacy, Medicinal Chemistry, Oncology +14

A Second-Generation Total Synthesis of (+)-Discodermolide:  The Development of a Practical Route Using Solely Substrate-Based Stereocontrol

Ian Paterson, Óscar Delgado, Gordon J. Florence et al. · The Journal of Organic Chemistry · 2004 · 71 citations

Natural Sciences, Chemistry, Medicinal Chemistry +13