Arno Paessens

Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication

J P Kleim, R. Bender, U M Billhardt et al. · Antimicrobial Agents and Chemotherapy · 1993 · 115 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication

J P Kleim, R. Bender, Reinhard Kirsch et al. · Antimicrobial Agents and Chemotherapy · 1995 · 85 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

J P Kleim, Manfred Rösner, Irvin Winkler et al. · Proceedings of the National Academy of Sciences · 1996 · 83 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720

Jan Balzarini, Anna Karlsson, C Meichsner et al. · Journal of Virology · 1994 · 44 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Mutational Analysis of Residue 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Jőrg‐Peter Kleim, Rudolf Bender, Reinhard Kirsch et al. · Virology · 1994 · 44 citations

Life Sciences, Molecular Biology, Molecular Genetics +7