The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

Lihua Jin, Xuhui Feng, Hui Rong, +12

Nature Communications

Antiparasitic Drug IvermectinAntiparasitic AgentMedicineDrug DiscoveryMechanism Of Action +5

STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression

Jaw‐Yuan Wang, Jie Sun, M-Y Huang, +9

Oncogene

Tumor BiologyMedicineColorectal CancerCancer BiologyStim1 Overexpression +6

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

Xiuchao Wang, Yunzhan Li, Zekun Li, +13

Cancer Research

Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression

Shengchen Lin, Yunzhan Li, Dezhen Wang, +10

Cancer Letters

MedicineAutophagyLung Cancer GrowthTumor SuppressorPfkfb3 Expression +8

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

Shengchen Lin, Chongbiao Huang, Venugopal Gunda, +9

Cell Reports

Monoubiquitination Inhibits the Actin Bundling Activity of Fascin

Shengchen Lin, Shuang Lü, Mentor Mulaj, +7

Journal of Biological Chemistry

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Shengchen Lin, Chongbiao Huang, Jianwei Sun, +10

EMBO Molecular Medicine

Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity

Yi Lu, Weili Zheng, Shengchen Lin, +7

Molecular Pharmacology

Structural Basis for Iloprost as a Dual Peroxisome Proliferator-activated Receptor α/δ Agonist

Lihua Jin, Shengchen Lin, Hui Rong, +4

Journal of Biological Chemistry

Revealing a steroid receptor ligand as a unique PPARγ agonist

Shengchen Lin, Ying Han, Yuzhe Shi, +6

Cell Research

Molecular PharmacologySignal TransductionG Protein-coupled ReceptorMedicinePhysiology +6