Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ

Lihua Jin, Dariusz Martynowski, Songyang Zheng, +3

Molecular Endocrinology

Proteinlipid InteractionRorgamma PocketMolecular BiologyRorgamma Ligand-binding DomainChemical Biology +14

Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Lili Ding, Kyle M. Sousa, Lihua Jin, +14

Hepatology

The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

Lihua Jin, Xuhui Feng, Hui Rong, +12

Nature Communications

Antiparasitic Drug IvermectinAntiparasitic AgentMedicineDrug DiscoveryMechanism Of Action +5

Axin Utilizes Distinct Regions for Competitive MEKK1 and MEKK4 Binding and JNK Activation

Wen Luo, Wilson W. Ng, Lihua Jin, +3

Journal of Biological Chemistry

Molecular BiologyCompetitive Mekk1CytoskeletonCellular PhysiologySignaling Pathway +14

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

Eryun Zhang, Lihua Jin, Yangmeng Wang, +13

Nature Communications

Detection of point mutations of the Axin1 gene in colorectal cancers

Lihua Jin, Wen Luo, Zhiyun Ye, +2

International Journal of Cancer

Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency

Weili Zheng, Lin Qiu, Rui Wang, +7

Scientific Reports

Axin Contains Three Separable Domains That Confer Intramolecular, Homodimeric, and Heterodimeric Interactions Involved in Distinct Functions

Wen Luo, Haiying Zou, Lihua Jin, +5

Journal of Biological Chemistry

Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease

Lihua Jin, Rui Wang, Yanlin Zhu, +5

Scientific Reports

Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice

Lili Ding, Eryun Zhang, Qiaoling Yang, +15

Proceedings of the National Academy of Sciences