Zisheng Fan

Sequence-based drug design as a concept in computational drug design

Lifan Chen, Zisheng Fan, Jie Chang et al. · Nature Communications · 2023 · 114 citations · Full text

Pharmacy, Bioinformatics, Drug Design +4

Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations

Chuan Zhou, Zisheng Fan, Zehui Zhou et al. · Journal of Medicinal Chemistry · 2022 · 81 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +10

Drug target inference by mining transcriptional data using a novel graph convolutional network framework

Feisheng Zhong, Xiaolong Wu, Ruirui Yang et al. · Protein & Cell · 2021 · 49 citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +16

Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers

Zehui Zhou, Guizhen Zhou, Chuan Zhou et al. · Journal of Medicinal Chemistry · 2023 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +13

Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS^G12D

Chuan Zhou, Zisheng Fan, Yuejiao Gu et al. · Journal of Medicinal Chemistry · 2024 · 37 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13