Haruyuki Takemura

Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes

Takahisa Furuta, Haruyuki Takemura, Zhi-Yong Liao et al. · Journal of Biological Chemistry · 2003 · 446 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.

Qiang Yu, JiHyun La Rose, Hongliang Zhang et al. · PubMed · 2002 · 140 citations

Medicine, Molecular Biology, Oncology +17

Tetrandrine Induces Early G1 Arrest in Human Colon Carcinoma Cells by Down-Regulating the Activity and Inducing the Degradation of G1-S–Specific Cyclin-Dependent Kinases and by Inducing p53 and p21Cip1

Linghua Meng, Hongliang Zhang, Larry Hayward et al. · Cancer Research · 2004 · 120 citations

Medicine, Oncology, Pharmacology +14

Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks

Haruyuki Takemura, V. Ashutosh Rao, Olivier Sordet et al. · Journal of Biological Chemistry · 2006 · 107 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine

Takahisa Furuta, Richard L. Hayward, L-h Meng et al. · Oncogene · 2005 · 42 citations

Life Sciences, Molecular Biology, Oncology +14