Brett A. O’Brien

Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

Nathalie Niyonzima, Jubayer Rahman, Natalia Kunz et al. · Science Immunology · 2021 · 135 citations · Full text

Intracellular sodium elevation reprograms cardiac metabolism

Dunja Aksentijević, Anja Karlstaedt, Marina Basalay et al. · Nature Communications · 2020 · 83 citations · Full text

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria

Flora Scott, Sandra G. Gonzalez Malagon, Brett A. O’Brien et al. · Drug Metabolism and Disposition · 2017 · 46 citations · Full text

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

Sevasti Zervou, Xiaoke Yin, Adam Nabeebaccus et al. · Amino Acids · 2016 · 18 citations · Full text

Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption

Neil A. Miller, Rebecca H. Graves, Chris D. Edwards et al. · Clinical Pharmacokinetics · 2021 · 14 citations · Full text