Development of a Grp94 inhibitor

Adam S. Duerfeldt, Laura B. Peterson, Jason C. Maynard, +8

Journal of the American Chemical Society

Molecular PharmacologyProtein Quality ControlProtein FunctionSignal TransductionHsp90 Inhibitors +13

Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

Amirthaa Suntharalingam, Jose F. Abisambra, John C. O’Leary, +12

Journal of Biological Chemistry

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Vincent M. Crowley, Anuj Khandelwal, Sanket J. Mishra, +9

Journal of Medicinal Chemistry

Cycloadditions of Noncomplementary Substituted 1,2,3-Triazines

Erin D. Anderson, Adam S. Duerfeldt, Kaicheng Zhu, +2

Organic Letters

Combinatorial ChemistryCross-coupling ReactionHeterocyclicFunctionalized HeterocyclesSubstituted 1,2,3-Triazines +6

Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation

Xiao-Jing Di, Yajuan Wang, Dong-Yun Han, +4

Journal of Biological Chemistry

Protein FunctionSignal TransductionBiochemistryNatural SciencesCell Biology +6

Total Syntheses of (−)-Pyrimidoblamic Acid and P-3A

Adam S. Duerfeldt, Dale L. Boger

Journal of the American Chemical Society

Bioorganic ChemistryEngineeringBiochemistryPyrimidine CoresNatural Sciences +12

Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding

Nanette L. S. Que, Vincent M. Crowley, Adam S. Duerfeldt, +4

Journal of Medicinal Chemistry

Drug TargetProtein AssemblyFlipped PoseMolecular BiologyChemical Biology +16

Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P

Nathan Lavey, Jesse A. Coker, Eliza A. Ruben, +1

Journal of Natural Products

Caseinolytic Protease PAntimicrobial Drug DiscoveryBiochemistryMedicineNatural Sciences +11

Hsp90 inhibition: Elimination of shock and stress

Adam S. Duerfeldt, Brian S. J. Blagg

Bioorganic & Medicinal Chemistry Letters

Reductive StressSignal TransductionStress HormoneMedicineHsp90 Inhibition +2

<i>Clostridium difficile</i> ClpP Homologues are Capable of Uncoupled Activity and Exhibit Different Levels of Susceptibility to Acyldepsipeptide Modulation

Nathan Lavey, Tyler M. Shadid, Jimmy D. Ballard, +1

ACS Infectious Diseases

Caseinolytic Protease PDistant IsoformsBiochemistryMedicineExhibit Different Levels +13