Sarah M. Groves

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

Carl M. Gay, C. Allison Stewart, Elizabeth M. Park et al. · Cancer Cell · 2021 · 864 citations · Full text

Immunogenetics, Systems Biology, Distinct Therapeutic Vulnerabilities +11

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

David J. Wooten, Sarah M. Groves, Darren R. Tyson et al. · PLoS Computational Biology · 2019 · 113 citations · Full text

Engineering, Subtype Gene Signatures, Gene Regulatory Network +18

ASCL1 represses a SOX9 ⁺ neural crest stem-like state in small cell lung cancer

Rachelle R. Olsen, Abbie S. Ireland, David W. Kastner et al. · Genes & Development · 2021 · 72 citations · Full text

Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer

Sarah M. Groves, Geena V. Ildefonso, Caitlin O. McAtee et al. · Cell Systems · 2022 · 55 citations · Full text

Intratumoral Heterogeneity, Lineage Plasticity, Tumor Heterogeneity +13

Beyond Programmed Death-Ligand 1: B7-H6 Emerges as a Potential Immunotherapy Target in SCLC

Portia Thomas, Sarah M. Groves, Yun-Kai Zhang et al. · Journal of Thoracic Oncology · 2021 · 31 citations · Full text