Robert J. Pignolo

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson, Larissa Prata, Shane A. Bobart et al. · EBioMedicine · 2019 · 1.3K citations · Full text

Veterinary Medicine, Pharmacology, Pharmacotherapy +17

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr, Ming Xu, Megan Weivoda et al. · Nature Medicine · 2017 · 1.1K citations · Full text

Medicine, Geriatric Medicine, Aging +9

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson et al. · Nature Communications · 2022 · 969 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation

Vincent J. Cristofalo, Robert G. Allen, Robert J. Pignolo et al. · Proceedings of the National Academy of Sciences · 1998 · 554 citations

Education, Cell Biology, Aging +8

v-ATPase V0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formation

Seoung-Hoon Lee, Jaerang Rho, Daewon Jeong et al. · Nature Medicine · 2006 · 541 citations

Medicine, Cell Biology, Molecular Biology +10