Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Xingyue He, Jessica Riceberg, Teresa A. Soucy, +26

Nature Chemical Biology

Selective Sae InhibitorOncogenic AgentMedicineNatural SciencesMolecular Biology +8

Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy

George Mulligan, David I. Lichter, Alessandra Di Bacco, +23

Blood

Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924

Jonathan L. Blank, Xiaozhen J. Liu, Katherine Cosmopoulos, +9

Cancer Research

ApoptosisMolecular BiologyCell DeathCell CycleCancer Biology +14

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

Margit Hagel, Deqiang Niu, Thia St Martin, +11

Nature Chemical Biology

Selective Irreversible InhibitionBiochemistryProtein FoldingNatural SciencesMedicine +6

The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity

Erik Koenig, Craig D. Fisher, Hugues Bernard, +10

BMC Genomics

Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

Hua Liao, Xiaozhen J. Liu, Jonathan L. Blank, +4

Molecular & Cellular Proteomics

Cullin-ring Ubiquitin LigasesAmino AcidsMolecular BiologyQuantitative Proteomic AnalysisProteomic Technology +15

Identification of a lung cancer cell line deficient in atg7-dependent autophagy

Jonathan Mandelbaum, Neil Rollins, Pooja Shah, +9

Autophagy

Identification of microRNA biomarker candidates in urine and plasma from rats with kidney or liver damage

Francis S. Wolenski, Pooja Shah, Tomoya Sano, +11

Journal of Applied Toxicology

The hamster adrenal cytochrome P450C11 has equipotent 11β-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity

Steeve Véronneau, Hugues Bernard, M. Cloutier, +5

The Journal of Steroid Biochemistry and Molecular Biology

Molecular PharmacologyAdrenal GlandBiochemistryMedicineAldosterone Synthase Activity +8

KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

Nibedita Chattopadhyay, Allison Berger, Erik Koenig, +16

PLoS ONE

ImmunologyPathologyKras-wt Sw48 CellsCancer BiologyTumor Biology +15