Rob Kastelein

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

Life Sciences, Cell Biology, Immunology +15

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

F Rousset, Elisabeth Garcia, Thierry Defrance et al. · Proceedings of the National Academy of Sciences · 1992 · 1.3K citations

Life Sciences, Cell Biology, Immunology +17

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

Paulo Vieira, René de Waal Malefyt, M N Dang et al. · Proceedings of the National Academy of Sciences · 1991 · 752 citations

Life Sciences, Genetics, Immunology +10

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

Douglas S. Robinson, Kazuko Shibuya, Alice Mui et al. · Immunity · 1997 · 723 citations · Full text

Life Sciences, Immunology, Cell Signaling +13

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

Ning Go, Brian E. Castle, Rachel Barrett et al. · The Journal of Experimental Medicine · 1990 · 482 citations · Full text

Life Sciences, Cell Biology, Immunology +17