Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

Joyce V. Lee, Alessandro Carrer, Supriya Shah, +19

Cell Metabolism

ChromatinChromatin RemodelingMetabolic ReprogrammingMedicineMetabolic Remodeling +3

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

Steven Zhao, Cholsoon Jang, Joyce Liu, +14

Nature

BiochemistryLipid NutritionLiver PhysiologyMicrobiota-derived AcetateMicrobiology +3

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Oliver G. McDonald, Xin Li, Tyler Saunders, +15

Nature Genetics

Pancreatic CancerMetabolic ReprogrammingEpigenomic ReprogrammingAnabolic Glucose MetabolismMedicine +9

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

Steven Zhao, AnnMarie Torres, Ryan A. Henry, +16

Cell Reports

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

Alessandro Carrer, Sophie Trefely, Steven Zhao, +15

Cancer Discovery

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

Sharanya Sivanand, Seth D. Rhoades, Qinqin Jiang, +12

Molecular Cell

BiosynthesisNatural SciencesProtein BiosynthesisMolecular BiologyDna Replication +5

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels

Alessandro Carrer, Joshua L.D. Parris, Sophie Trefely, +10

Journal of Biological Chemistry

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca²⁺–NFAT signaling

Joyce V. Lee, Corbett T. Berry, Karla Kim, +13

Genes & Development

Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis

Luke Izzo, Sophie Trefely, Christina Demetriadou, +15

Science Advances

Stable Isotope TracingCell CycleMetabolic RemodelingLinks Mitochondrial MetabolismOxidative Stress +17

Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice

Serena Zacchigna, Lucia Pattarini, Lorena Zentilin, +7

Journal of Clinical Investigation