Heparanase Enhances Syndecan-1 Shedding

Yang Yang, Veronica MacLeod, Hua‐Quan Miao, +8

Journal of Biological Chemistry

PathologyCancer BiologyTumor BiologyHeparanase RegulationHeparan Sulfate Chains +15

Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior

Eyal Zcharia, Shula Metzger, Tova Chajek‐Shaul, +7

The FASEB Journal

Human HeparanaseEmbryologyHpa-tg MiceMetabolismKidney Tubule Remodeling +15

Heparanase Gene Silencing, Tumor Invasiveness, Angiogenesis, and Metastasis

Evgeny Edovitsky, Michael Elkin, Eyal Zcharia, +2

JNCI Journal of the National Cancer Institute

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

Sara Massena, Gustaf Christoffersson, Elina Hjertström, +6

Blood

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

Natali Gil, Rachel Goldberg, Tzahi Neuman, +10

Diabetes

Renal PathologyGlycobiologyDn PathogenesisOxidative StressGlomerulonephritis +14

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

Immanuel Lerner, Esther Hermano, Eyal Zcharia, +11

Journal of Clinical Investigation

<i>In vivo</i> fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis

Jin‐Ping Li, Martha L. Escobar Galvis, Gong Feng, +6

Proceedings of the National Academy of Sciences

Heparanase mediates cell adhesion independent of its enzymatic activity

Orit Goldshmidt, Eyal Zcharia, Miriam Cohen, +6

The FASEB Journal

BiochemistryEnzymatic ActivityCell SignalingCell AdhesionNatural Sciences +13

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases

Eyal Zcharia, Juan Jia, Xiao Zhang, +5

PLoS ONE

Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis

Orit Goldshmidt, Eyal Zcharia, Rinat Abramovitch, +6

Proceedings of the National Academy of Sciences