Heparanase Gene Silencing, Tumor Invasiveness, Angiogenesis, and Metastasis

Abstract

The association of reduced levels of heparanase and altered tumorigenic properties in cells with anti-heparanase ribozyme- or siRNA-mediated gene-silencing vectors suggests that heparanase is important in cancer progression. Heparanase gene silencing has potential use as a target for anticancer drug development.