Tigran M. Abramyan

AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach, Denzil Bernard, Kong T. Nguyen et al. · Scientific Reports · 2024 · 120 citations · Full text

Pharmacy, Bioinformatics, Medicinal Chemistry +16

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

David Dilworth, Ronan P. Hanley, Renato Ferreira de Freitas et al. · Nature Chemical Biology · 2021 · 107 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +7

Cluster analysis of molecular simulation trajectories for systems where both conformation and orientation of the sampled states are important

Tigran M. Abramyan, James A. Snyder, Aby A. Thyparambil et al. · Journal of Computational Chemistry · 2016 · 46 citations

Natural Sciences, Biophysics, Computational Biophysics +16

An atypical heterotrimeric Gα protein has substantially reduced nucleotide binding but retains nucleotide-independent interactions with its cognate RGS protein and Gβγ dimer

Fei Lou, Tigran M. Abramyan, Haiyan Jia et al. · Journal of Biomolecular Structure and Dynamics · 2019 · 23 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors

Artur Meller, Saulo De Oliveira, Aram Davtyan et al. · Frontiers in Molecular Biosciences · 2023 · 22 citations · Full text

Engineering, Biophysics, Molecular Biology +14