Susan E. Kiefer

The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants

John S. Tokarski, John A. Newitt, Chieh Ying J. Chang et al. · Cancer Research · 2006 · 686 citations · Full text

Medicine, Medicinal Chemistry, Oncology +13

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

John S. Sack, Kevin Kish, Chihuei Wang et al. · Proceedings of the National Academy of Sciences · 2001 · 485 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface

S. Donald Emerson, Vincent Madison, Robert E. Palermo et al. · Biochemistry · 1995 · 110 citations

Life Sciences, Biophysics, Molecular Biology +16

Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-<i>f</i>][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors

John Hynes, Alaric J. Dyckman, Shuqun Lin et al. · Journal of Medicinal Chemistry · 2007 · 82 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP.

Julie E. Scheffler, David S. Waugh, Eva Bekesi et al. · Journal of Biological Chemistry · 1994 · 58 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17