Revealing Atropisomer Axial Chirality in Drug Discovery

Steven R. LaPlante, Paul Edwards, Lee D. Fader, +2

ChemMedChem

Molecular PharmacologyMedicinal ChemistryMolecular SciencesEngineeringBiochemistry +13

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

Lee D. Fader, Richard C. Bethell, Pierre Bonneau, +22

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryNatural Sciences +6

Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions

Alexander Sedykh, Denis Fourches, Jianmin Duan, +5

Pharmaceutical Research

Drug TargetQsar ModelingMedicineGastroenterologyDrug Uptake +6

The Protein Farnesyltransferase Inhibitor Tipifarnib as a New Lead for the Development of Drugs against Chagas Disease

Oliver Hucke, Michael H. Gelb, Christophe L. M. J. Verlinde, +1

Journal of Medicinal Chemistry

Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype <i>In Vivo</i>

Catherine Spickler, Julie Lippens, Marie-Kristine Laberge, +11

Antimicrobial Agents and Chemotherapy

Resistance to a Protein Farnesyltransferase Inhibitor in Plasmodium falciparum

Richard T. Eastman, John White, Oliver Hucke, +8

Journal of Biological Chemistry

Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor

Noureldin Saleh, Oliver Hucke, Gert Kramer, +7

Angewandte Chemie International Edition

Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335

Christopher T. Lemke, Nathalie Goudreau, Songping Zhao, +4

Journal of Biological Chemistry

Virus StructureBiochemistryProtein FoldingViral HepatitisNatural Sciences +8

Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity

Steven R. LaPlante, Pat Forgione, Colette Boucher, +11

Journal of Medicinal Chemistry

Molecular BiologyAntiviral DrugChemical BiologyMedicinal ChemistryAtropisomer Chirality +18

Discovery and Structural Characterization of a New Inhibitor Series of HIV-1 Nucleocapsid Function: NMR Solution Structure Determination of a Ternary Complex Involving a 2:1 Inhibitor/NC Stoichiometry

Nathalie Goudreau, Oliver Hucke, Anne‐Marie Faucher, +5

Journal of Molecular Biology

BiochemistryNatural SciencesOligonucleotideMolecular BiologyStructure Elucidation +8