Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease

Maurício M. Oliveira, Mychael V. Lourenco, Francesco Longo, +10

Science Signaling

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

Maria Daniela Cirnaru, Antonella Marte, Elisa Belluzzi, +14

Frontiers in Molecular Neuroscience

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

Emanuela Santini, Thu N. Huynh, Francesco Longo, +5

Science Signaling

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

Francesco Longo, Daniela Mercatelli, Salvatore Novello, +12

Acta Neuropathologica Communications

Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling

Megan Allen, Ben Huang, Michael Notaras, +12

Molecular Psychiatry

Cognitive Impairment and Dentate Gyrus Synaptic Dysfunction in Experimental Parkinsonism

Alessandra Bonito-Oliva, Marco Pignatelli, Giada Spigolon, +8

Biological Psychiatry

Synaptic PlasticityNeuropsychologyBrain FunctionMedicineCortical Remodeling +6

Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

Prerana Shrestha, Pinar Ayata, Pedro Herrero-Vidal, +5

Nature Neuroscience

Neurodegenerative DiseasesMolecular NeuroscienceMemory SystemMemory ConsolidationMemory +8

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

Francesco Longo, Isabella Russo, Derya R. Shimshek, +2

Neurobiology of Disease

d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain

Luigia Cristino, Livio Luongo, Marta Squillace, +14

Neurobiology of Aging

NeurophysiologyMammalian BrainNeuropharmacologyNeuroprotectionNeuroscience +5

UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function

Michael Notaras, Megan Allen, Francesco Longo, +5

Molecular Psychiatry

Synaptic PlasticityTranscriptional RegulationSignal TransductionMolecular NeuroscienceSignaling Pathway +8