Marlene A. Bunni

A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance

Gerrit Jansen, Robert Mauritz, Stavit Drori et al. · Journal of Biological Chemistry · 1998 · 163 citations · Full text

Medicine, Oncology, Pharmacology +15

Loss of folylpoly‐γ‐glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation‐dependent novel antifolates in multiple human leukemia sublines

Esti Liani, Lilah Rothem, Marlene A. Bunni et al. · International Journal of Cancer · 2002 · 117 citations · Full text

Medicine, Oncology, Pharmacology +14

Pharmacokinetics of Leucovorin Metabolites in Human Plasma as a Function of Dose Administrated Orally and Intravenously

David G. Priest, John C. Schmitz, Marlene A. Bunni et al. · JNCI Journal of the National Cancer Institute · 1991 · 88 citations

Medicine, Pharmacokinetics, Pharmacology +7

Multiple Mechanisms of Resistance to Polyglutamatable and Lipophilic Antifolates in Mammalian Cells: Role of Increased Folylpolyglutamylation, Expanded Folate Pools, and Intralysosomal Drug Sequestration

Gerrit Jansen, Haim Barr, Ietje Kathmann et al. · Molecular Pharmacology · 1999 · 67 citations

Veterinary Medicine, Biochemistry, Pharmacology +17

Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.

C.L. van der Wilt, Harold H.J. Backus, Kees Smid et al. · PubMed · 2001 · 63 citations

Medicine, Oncology, Pharmacology +14