Gregory R. J. Thatcher

Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

Zhengnan Shen, Kiira Ratia, Laura Cooper et al. · Journal of Medicinal Chemistry · 2021 · 211 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +16

Phosphonates as mimics of phosphate biomolecules: ab initio calculations on tetrahedral ground states and pentacoordinate intermediates for phosphoryl transfer

Gregory R. J. Thatcher, A. Stewart Campbell · The Journal of Organic Chemistry · 1993 · 142 citations

Natural Sciences, Biochemistry, Chemistry +11

Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein

Irida Kastrati, Marton I. Siklos, Esther L. Calderon-Gierszal et al. · Journal of Biological Chemistry · 2015 · 141 citations · Full text

Life Sciences, Molecular Biology, Oncology +8

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

Lei Yu, Shinya Tasaki, Julie A. Schneider et al. · JAMA Psychiatry · 2020 · 139 citations · Full text

Medicine, Neurology, Neuroscience +17

Benzothiophene Selective Estrogen Receptor Modulators with Modulated Oxidative Activity and Receptor Affinity

Zhihui Qin, Irida Kastrati, R. Esala P. Chandrasena et al. · Journal of Medicinal Chemistry · 2007 · 138 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16