Zhengnan Shen

Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

Zhengnan Shen, Kiira Ratia, Laura Cooper et al. · Journal of Medicinal Chemistry · 2021 · 205 citations · Full text

Molecular Docking, Medicine, Sars-cov-2 Plpro Inhibitors +13

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

Zhengnan Shen, Kiira Ratia, Laura Cooper et al. · 2021 · 40 citations · Full text

Whereas Plpro, Human Cell Cultures, Viral Replication +14

XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer

Daniel R. Principe, Rui Xiong, Yangfeng Li et al. · Proceedings of the National Academy of Sciences · 2022 · 40 citations · Full text

Immunology, Pathology, Immunotherapy +17

Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer

Yunlong Lu, Lauren M. Gutgesell, Rui Xiong et al. · Journal of Medicinal Chemistry · 2019 · 39 citations · Full text

Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib

Yangfeng Li, Jiong Zhao, Lauren M. Gutgesell et al. · Journal of Medicinal Chemistry · 2020 · 33 citations · Full text