Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy

Randy J. Chandler, Matthew C. LaFave, Gaurav K. Varshney, +8

Journal of Clinical Investigation

ImmunologyPathologyGene DeliveryAav Vector DoseCancer-associated Virus +16

Macrophage Depletion Combined with Anticoagulant Therapy Increases Therapeutic Window of Systemic Treatment with Oncolytic Adenovirus

Elena V. Shashkova, Konstantin Doronin, Julien S. Senac, +1

Cancer Research

Comparison of Replication-Competent, First Generation, and Helper-Dependent Adenoviral Vaccines

Eric A. Weaver, Pramod N. Nehete, Stephanie S. Buchl, +5

PLoS ONE

VaccinationVaccine DevelopmentHuman RetrovirusImmunologyAntiviral Response +10

Infection and Killing of Multiple Myeloma by Adenoviruses

Julien S. Senac, Konstantin Doronin, Stephen J. Russell, +3

Human Gene Therapy

Viral PersistenceMedicineImmunologyOncolytic VirotherapyPathology +8

Adeno-Associated Virus Serotype 8 Gene Transfer Rescues a Neonatal Lethal Murine Model of Propionic Acidemia

Randy J. Chandler, Suma Chandrasekaran, Nuria Carrillo, +4

Human Gene Therapy

Gene Transfer ApproachKnockout MouseTranslational MedicineXenotransplantationPropionic Acidemia +13

Species D Adenoviruses as Oncolytics against B-cell Cancers

Christopher Y. Chen, Julien S. Senac, Eric A. Weaver, +5

Clinical Cancer Research

Short-Term Rescue of Neonatal Lethality in a Mouse Model of Propionic Acidemia by Gene Therapy

Sean Hofherr, Julien S. Senac, Christopher Y. Chen, +3

Human Gene Therapy

ImmunologyDisease Gene IdentificationEmbryologyPolyethylene GlycolShort-term Rescue +14

Gene therapy in a murine model of methylmalonic acidemia using rAAV9-mediated gene delivery

Julien S. Senac, Randy J. Chandler, Justin R. Sysol, +2

Gene Therapy

Gene TherapiesIn Vivo Gene TherapyMedicineMurine ModelImmunology +9

Systemic delivery of therapeutic viruses.

Michael A. Barry, Sean Hofherr, Christopher Y. Chen, +3

PubMed

Viral PathogenesisImmunologyAntiviral Drug DevelopmentVirologyDrug Delivery Systems +7

Macrophage derived TNFα promotes hepatic reprogramming to Warburg-like metabolism

Maxim Jestin, Shingo Matsumoto, Keita Saito, +10

Journal of Molecular Medicine

InflammationHepatologyLiver PhysiologyImmunologyMetabolic Regulation +5