Henry W. Pauls

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1<i>R</i>,2<i>S</i>)-2-(3-((<i>E</i>)-4-(((<i>cis</i>)-2,6-Dimethylmorpholino)methyl)styryl)-1<i>H</i>-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

Peter B. Sampson, Yong Liu, Bryan Forrest et al. · Journal of Medicinal Chemistry · 2014 · 166 citations · Full text

Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors

S. Maignan, J.P. Guilloteau, Stéphanie Pouzieux et al. · Journal of Medicinal Chemistry · 2000 · 139 citations · Full text

X-ray Crystallography, Crystal Structure, Protein Assembly +21

Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors:  Preference for a Neutral Group in the S1 Pocket

S. Maignan, J.P. Guilloteau, Yong Mi Choi-Sledeski et al. · Journal of Medicinal Chemistry · 2003 · 118 citations · Full text

Pharmaceutical Science, Drug Target, Molecular Biology +19

Mode of Action, <i>In Vitro</i> Activity, and <i>In Vivo</i> Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor

Nachum Kaplan, Monique Albert, Donald E. Awrey et al. · Antimicrobial Agents and Chemotherapy · 2012 · 109 citations · Full text

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3<i>H</i>]indol]-2′(1′<i>H</i>)-ones as Orally Bioavailable Antitumor Agents

Peter B. Sampson, Yong Liu, Narendra Kumar Patel et al. · Journal of Medicinal Chemistry · 2014 · 109 citations

Pharmaceutical Science, Polo-like Kinase Family, Compound 18 +22