Carcinogenicity of deoxycholate, a secondary bile acid

Carol Bernstein, Hana Holubec, A. K. Bhattacharyya, +4

Archives of Toxicology

NutritionBile Acid SecretionBiliary TractMedicineBiliary Cancer +12

Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett’s oesophagus

Katerina Dvorak, C. M Payne, Melissa Chavarria, +8

Gut

Deoxycholate induces mitochondrial oxidative stress and activates NF- B through multiple mechanisms in HCT-116 colon epithelial cells

C. M. Payne, Craig Weber, Cheray Crowley-Skillicorn, +6

Carcinogenesis

Nicotine increases oxidative stress, activates NF-κB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis

Cara L Crowley-Weber, Kateřina Dvořáková, Cheray Crowley, +4

Chemico-Biological Interactions

Redox SignalingGenotoxic/xenobiotic StressesMedicineNicotineMultiple Stress Inducer +7

A bile acid-induced apoptosis assay for colon cancer risk and associated quality control studies.

Carol Bernstein, Harris Bernstein, Harinder S. Garewal, +8

PubMed

Colonic Goblet CellsGastrointestinal OncologyColon Cancer RiskMedicineApoptosis +9

Bile Salt Activation of Stress Response Promoters in Escherichia coli

Carol Bernstein, Harris Bernstein, Claire M. Payne, +2

Current Microbiology

Transcriptional RegulationProtein ExpressionBiochemistryNatural SciencesBacteriology +8

Bile salt/acid induction of DNA damage in bacterial and mammalian cells: Implications for colon cancer

Risa Lynne. Kandell, Carol Bernstein

Nutrition and Cancer

Dna DamagePathologyDna Repair ResponseOxidative StressRadiation Oncology +14

The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate

Cara Crowley, C. M. Payne, Harris Bernstein, +2

Cell Death and Differentiation

Reductive StressBiochemistryMedicineNicotineApoptosis +9

Reduced bile acid-induced apoptosis in "normal" colorectal mucosa: a potential biological marker for cancer risk.

Harinder S. Garewal, Harris Bernstein, Carol Bernstein, +2

PubMed

GastroenterologyCell DeathPathologyCrc PatientsAcid-induced Apoptosis +14

The stress-response proteins poly(ADP-ribose) polymerase and NF-κB protect against bile salt-induced apoptosis

Claire M. Payne, Cara Crowley, Delon Washo-Stultz, +6

Cell Death and Differentiation

InflammationReductive StressStress-response ProteinsBiochemistryNf-κb Protect +11