Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer

Taekyu Lee, Plamen P. Christov, Subrata Shaw, +24

Journal of Medicinal Chemistry

Hematological MalignancyTumor BiologyMouse Xenograft ModelsVivo ActivityCompound 42 +13

Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Jianhua Tian, Kevin B. Teuscher, Erin R. Aho, +22

Journal of Medicinal Chemistry

Molecular DockingCombinatorial ChemistryMedicinal ChemistryWin SiteDrug Target +13

Fragment-based screening of programmed death ligand 1 (PD-L1)

Evan Perry, Jonathan J. Mills, Bin Zhao, +8

Bioorganic & Medicinal Chemistry Letters

Molecular DockingMedicinal ChemistryDrug TargetMedicineRational Drug Design +4

Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization

Kevin B. Teuscher, Kenneth M. Meyers, Qiangqiang Wei, +13

Journal of Medicinal Chemistry

Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3)

Tyson A. Rietz, Kevin B. Teuscher, Jonathan J. Mills, +7

Journal of Medicinal Chemistry

T-regulatory CellImmunologyMolecular BiologyImmunodominanceImmunologic Mechanism +19

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Jonathan J. Mills, Kaylib R. Robinson, Troy E. Zehnder, +1

Angewandte Chemie International Edition

Structural AnaloguesMedicinal ChemistryAntimicrobial Drug DiscoveryNatural Product SynthesisBiochemistry +13

Synthesis of the Cyanobacterial Antibiotics Anaephenes A and B

David L. Kukla, Juan Canchola, Jonathan J. Mills

Journal of Natural Products

Enantiospecific Synthesis of β-Substituted Tryptamines

Heather N. Rubin, Kinney Van Hecke, Jonathan J. Mills, +2

Organic Letters

A Ru(<scp>ii</scp>)-arene-ferrocene complex with promising antibacterial activity

Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, +5

Dalton Transactions

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Jonathan J. Mills, Kaylib R. Robinson, Troy E. Zehnder, +1

Angewandte Chemie

Lead CompoundsAntimicrobial ChemotherapyPharmaceutical ChemistryDrug ResistanceDiversity Oriented Synthesis +14