Lucy A. Young

Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells

Rebecca L. Lloyd, Paul W.G. Wijnhoven, Antonio Ramos‐Montoya et al. · Oncogene · 2020 · 186 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes

Ian Powley, Alexander Kondrashov, Lucy A. Young et al. · Genes & Development · 2009 · 145 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress

Lucy A. Young, Lenka Oplustil O'Connor, Christelle de Renty et al. · Cancer Research · 2019 · 71 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry

Gemma N. Jones, Claire Rooney, Nicola Griffin et al. · British Journal of Cancer · 2018 · 36 citations · Full text

Medicine, Oncology, Pharmacology +17

Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation

Marta López‐Peláez, Lucy A. Young, Mercedes Vázquez–Chantada et al. · OncoImmunology · 2022 · 31 citations · Full text

Life Sciences, Immunology, Oncology +17