Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Jerry H. Houl, Zu Ye, Chris A. Brosey, +18

Nature Communications

Morphological observation and analysis using automated image cytometry for the comparison of trypan blue and fluorescence-based viability detection method

Leo Li‐Ying Chan, Dmitry Kuksin, Daniel J. Laverty, +2

Cytotechnology

Microscope Image ProcessingMicroscopyImage CytometryBioimage AnalysisBiomedical Imaging +9

Accurate measurement of peripheral blood mononuclear cell concentration using image cytometry to eliminate RBC-induced counting error

Leo Li‐Ying Chan, Daniel J. Laverty, Tim Smith, +5

Journal of Immunological Methods

Image CytometryMedicineBioanalysisHematologyBlood Cell +10

Large-scale preparation of fluorescence multiplex host cell reactivation (FM-HCR) reporters

Cortt G. Piett, Turner Pecen, Daniel J. Laverty, +1

Nature Protocols

MicroscopyReporter Gene AssayLarge-scale PreparationMolecular BiologySingle-molecule Detection +4

Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization

Jiajia Chen, Daniel J. Laverty, Surabhi Talele, +16

Science Translational Medicine

ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma

Daniel J. Laverty, Shiv K. Gupta, Gary A. Bradshaw, +7

Nature Communications

CDK-independent role of D-type cyclins in regulating DNA mismatch repair

Gergely Róna, Bearach Miwatani-Minter, Qingyue Zhang, +21

Molecular Cell

Reductive StressChromatinTranscriptional RegulationGenome InstabilityCell Regulation +13

ATM phosphorylates the FATC domain of DNA-PKcs at threonine 4102 to promote non-homologous end joining

Huiming Lu, Qin Zhang, Daniel J. Laverty, +6

Nucleic Acids Research

Dna DamageProtein AssemblyMolecular RegulationGenomic MechanismMolecular Biology +16

Selective Inhibition of DNA Polymerase β by a Covalent Inhibitor

Shelby C. Yuhas, Daniel J. Laverty, Huijin Lee, +2

Journal of the American Chemical Society

The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase θ

Daniel J. Laverty, April M. Averill, Sylvie Doublié, +1

ACS Chemical Biology

ChromatinDna Polymerase θBiosynthesisPol θNucleic Acid Chemistry +10