WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Edmond M. Chan, Tsukasa Shibue, James M. McFarland, +38

Nature

Microsatellite Unstable CancersOncogenic AgentMedicineMolecular BiologyCancer Genomics +6

Adaptive mutability of colorectal cancers in response to targeted therapies

Mariangela Russo, Giovanni Crisafulli, Alberto Sogari, +20

Science

PathologyCancer BiologyTumor BiologyDrug ResistanceOncology +14

Silver nanoparticles (AgNPs) cause degeneration of cytoskeleton and disrupt synaptic machinery of cultured cortical neurons

Fenglian Xu, Cortt G. Piett, Svetlana Farkas, +2

Molecular Brain

The CHD6 chromatin remodeler is an oxidative DNA damage response factor

Shaun Moore, N. Daniel Berger, Martijn S. Luijsterburg, +9

Nature Communications

Structural and functional characterization of the PNKP–XRCC4–LigIV DNA repair complex

R. Daniel Aceytuno, Cortt G. Piett, Zahra Havali-Shahriari, +12

Nucleic Acids Research

Nhej Scaffolding ProteinXrcc4 Coiled-coilNucleic Acid ChemistryProtein FunctionProtein Assembly +12

Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells.

Adam Y. Xiao, Matthew Maynard, Cortt G. Piett, +8

Redox Biology

Exploiting DNA repair defects in triple negative breast cancer to improve cell killing

Kevin J. Lee, Elise Mann, Griffin Wright, +3

Therapeutic Advances in Medical Oncology

Large-scale preparation of fluorescence multiplex host cell reactivation (FM-HCR) reporters

Cortt G. Piett, Turner Pecen, Daniel J. Laverty, +1

Nature Protocols

MicroscopyReporter Gene AssayLarge-scale PreparationMolecular BiologySingle-molecule Detection +4

Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer

Kevin J. Lee, Cortt G. Piett, Joel Andrews, +3

PLoS ONE

Breast OncologyDna DamageDna Repair DefectsMolecular BiologyPathology +14

CDK-independent role of D-type cyclins in regulating DNA mismatch repair

Gergely Róna, Bearach Miwatani-Minter, Qingyue Zhang, +21

Molecular Cell

Reductive StressChromatinTranscriptional RegulationGenome InstabilityCell Regulation +13