Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2

Claudia Binda, Sérgio Valente, Mauro Romanenghi, +11

Journal of the American Chemical Society

Drug TargetChromatin StateLsd2 Histone DemethylasesChemical BiologyPharmaceutical Chemistry +14

Phosphorylation of neuronal Lysine‐Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2

Emanuela Toffolo, Francesco Rusconi, Leda Paganini, +9

Journal of Neurochemistry

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

Simona Pilotto, Valentina Speranzini, Marcello Tortorici, +8

Proceedings of the National Academy of Sciences

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features

Valentina Speranzini, Dante Rotili, Giuseppe Ciossani, +9

Science Advances

Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase

Marcello Tortorici, María Teresa Borrello, Maria Tardugno, +13

ACS Chemical Biology

Protein AssemblyMolecular BiologyProtein ComplexesCombinatorial AssemblyProteomics +16

LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors

Simona Pilotto, Valentina Speranzini, Chiara Marabelli, +5

Human Molecular Genetics

Histone ModificationsGene ProductEpigenetic ChangeGeneticsGenomic Mechanism +14

The cutting edge of archaeal transcription

Thomas Fouqueau, Fabian Blombach, Gwenny Cackett, +6

Emerging Topics in Life Sciences

Transcriptional RegulationMedicineNatural SciencesTranscription RegulationNucleic Acid Biochemistry +12

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex

Chiara Marabelli, Biagina Marrocco, Simona Pilotto, +10

Cell Reports

Protein AssemblyEpigenetic ChangeMolecular BiologyRapid Chromatin ModificationNucleosome Demethylation +20

Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations

Marco Montefiori, Simona Pilotto, Chiara Marabelli, +5

Journal of Chemical Information and Modeling

Molecular RegulationMolecular BiologyEpigeneticsMolecular DynamicsMolecular Design +21

Structural basis of RNA polymerase inhibition by viral and host factors

Simona Pilotto, Thomas Fouqueau, Natalya Lukoyanova, +7

Nature Communications