Lydia Chang

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked <i>UBQLN2</i> mutations

Nhat T. T. Le, Lydia Chang, Irina Kovlyagina et al. · Proceedings of the National Academy of Sciences · 2016 · 87 citations · Full text

Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations

Lydia Chang, Mervyn J. Monteiro · PLoS ONE · 2015 · 78 citations · Full text

Protein Assembly, Ubiquitinated Proteins, Proteasome +16

ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1

Kathleen M. Gilpin, Lydia Chang, Mervyn J. Monteiro · Human Molecular Genetics · 2015 · 59 citations · Full text

Ubiquilin-1 Overexpression Increases the Lifespan and Delays Accumulation of Huntingtin Aggregates in the R6/2 Mouse Model of Huntington's Disease

Nathaniel Safren, Amina El Ayadi, Lydia Chang et al. · PLoS ONE · 2014 · 38 citations · Full text

Mitophagy, Molecular Biology, Cell Autophagy +16

Signature changes in ubiquilin expression in the R6/2 mouse model of Huntington’s disease

Nathaniel Safren, Lydia Chang, Kristina M. Dziki et al. · Brain Research · 2014 · 16 citations · Full text

Knockout Mouse, Neurodegenerative Diseases, Ubiquilin Expression +8