Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked <i>UBQLN2</i> mutations

Nhat T. T. Le, Lydia Chang, Irina Kovlyagina, +14

Proceedings of the National Academy of Sciences

The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded<i>C9ORF72</i>Inhibits the Proteasome

Rahul Gupta, Matthews Lan, Jelena Mojsilovic-Petrovic, +5

eNeuro

Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly

Lisa M. Sharkey, Nathaniel Safren, Amit S. Pithadia, +12

Proceedings of the National Academy of Sciences

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

Ismael Al‐Ramahi, Sai Srinivas Panapakkam Giridharan, Yu‐Chi Chen, +17

eLife

Ubiquilin-1 Overexpression Increases the Lifespan and Delays Accumulation of Huntingtin Aggregates in the R6/2 Mouse Model of Huntington's Disease

Nathaniel Safren, Amina El Ayadi, Lydia Chang, +4

PLoS ONE

MitophagyMolecular BiologyCell AutophagyUbiquilin-1 OverexpressionHd Symptoms +14

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Kaitlin Weskamp, Nathaniel Safren, Roberto Miguez, +1

Journal of Visualized Experiments

Longitudinal Fluorescence MicroscopyCellular NeurobiologyCellular PhysiologySocial SciencesSingle Cell Sequencing +15

Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins

Julia E. Gerson, Hunter Linton, Jiazheng Xing, +8

Scientific Reports

Ubiquilin-2 differentially regulates polyglutamine disease proteins

Julia E. Gerson, Nathaniel Safren, Svetlana Fischer, +7

Human Molecular Genetics

Protein FunctionSignal TransductionAutoimmune DiseaseDisease MechanismPolyglutamine Disease Proteins +10

RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control

Harihar Milaganur Mohan, Hanna Trzeciakiewicz, Amit S. Pithadia, +10

Cellular and Molecular Life Sciences

Protein Quality ControlTranscriptional RegulationProtein FunctionMolecular BiologyNuclear Organization +5

Development of a specific live-cell assay for native autophagic flux

Nathaniel Safren, Elizabeth M.H. Tank, Ahmed M. Malik, +3

Journal of Biological Chemistry

MitophagyImmunologyCell DeathMolecular BiologyCell Culture +14