Michael Mertzman

Practical olefin hydroamination with nitroarenes

Jinghan Gui, Chung‐Mao Pan, Ying Jin et al. · Science · 2015 · 533 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Identification of <i>N</i>-Methyl Nicotinamide and <i>N</i>-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)

Ryan Moslin, Yanlei Zhang, Stephen T. Wrobleski et al. · Journal of Medicinal Chemistry · 2019 · 92 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity

X. Christopher Sheng, Anthony Casarez, Ruby Cai et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 48 citations

Medicine, Infectious Diseases, Medicinal Chemistry +12

Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

Martijn Fenaux, Stacey Eng, Stephanie A. Leavitt et al. · Antimicrobial Agents and Chemotherapy · 2012 · 42 citations · Full text

Life Sciences, Infectious Diseases, Medicinal Chemistry +17

Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection

Scott E. Lazerwith, Willard Lew, Jennifer Zhang et al. · Journal of Medicinal Chemistry · 2013 · 37 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17