Brent J. Ryan

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Hugo J. R. Fernandes, Elizabeth M. Hartfield, Helen Christian et al. · Stem Cell Reports · 2016 · 350 citations · Full text

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

Stephanie Janezic, Sarah Threlfell, Paul D. Dodson et al. · Proceedings of the National Academy of Sciences · 2013 · 342 citations · Full text

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

Charmaine Lang, Kieran R. Campbell, Brent J. Ryan et al. · Cell stem cell · 2018 · 185 citations · Full text

Neurodegenerative Diseases, Identifies Hdac4, Parkinson Cell Phenotypes +9

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons

Federico Zambon, Marta Cherubini, Hugo J. R. Fernandes et al. · Human Molecular Genetics · 2019 · 161 citations · Full text

Genetics, Synaptic Signaling, Social Sciences +28

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells

Amy Smith, Constanze Depp, Brent J. Ryan et al. · Movement Disorders · 2018 · 120 citations · Full text