Jelena Melesina

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from <i>Schistosoma mansoni</i> for the Treatment of Schistosomiasis

Tino Heimburg, Alokta Chakrabarti, Julien Lancelot et al. · Journal of Medicinal Chemistry · 2016 · 122 citations · Full text

Medicinal Chemistry, Smhdac8 Activity, Biochemistry +12

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

Martin Marek, T.B. Shaik, Tino Heimburg et al. · Journal of Medicinal Chemistry · 2018 · 115 citations · Full text

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

Johanna Senger, Jelena Melesina, Martin Marek et al. · Journal of Medicinal Chemistry · 2015 · 108 citations · Full text

Medicinal Chemistry, Hdac6 Inhibitors, Biochemistry +14

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

Tino Heimburg, Fiona R. Kolbinger, Patrik Zeyen et al. · Journal of Medicinal Chemistry · 2017 · 91 citations · Full text

Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni

Diana A. Stolfa, Martin Marek, Julien Lancelot et al. · Journal of Molecular Biology · 2014 · 71 citations · Full text

Crystal Structure, Antiparasitic Agent, Molecular Biology +18