Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer

Erik Kupperman, Edmund C. Lee, Yueying Cao, +16

Cancer Research

Proteasome Inhibitor Mln9708Antitumor ActivityImmunologyProteasomeMolecular Biology +19

Development of a Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes for the Synthesis of Endothelin-A Antagonist <b>ABT-546</b>. Scope, Mechanism, and Further Application to the Synthesis of the Antidepressant Rolipram

David M. Barnes, Jianguo Ji, Michael G. Fickes, +8

Journal of the American Chemical Society

Asymmetric CatalysisMedicinal Chemistry1,3-Dicarbonyl CompoundsFurther ApplicationBiochemistry +13

Mobocertinib (TAK-788): A Targeted Inhibitor of <i>EGFR</i> Exon 20 Insertion Mutants in Non–Small Cell Lung Cancer

Francois Gonzalvez, Sylvie Vincent, Theresa E. Baker, +23

Cancer Discovery

Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

Qun Li, Keith W. Woods, Akiyo Claiborne, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesTubulin Polymerization Inhibitors +10

Antitumor Activity of the Investigational Proteasome Inhibitor MLN9708 in Mouse Models of B-cell and Plasma Cell Malignancies

Edmund C. Lee, Michael Fitzgerald, Bret Bannerman, +20

Clinical Cancer Research

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery

Anar Murphy, Michael Fitzgerald, Teresa Ro, +5

The Journal of Cell Biology

ChromatinTranscriptional RegulationGenome InstabilityNatural SciencesGenetics +12

PKC-θ-Deficient Mice Are Protected from Th1-Dependent Antigen-Induced Arthritis

Aileen M. Healy, Elena S. Izmailova, Michael Fitzgerald, +10

The Journal of Immunology

ImmunologyImmune RegulationPathologyMusculoskeletal ResearchInflammatory Arthritis +15

Recombinant Human Interleukin-11 Directly Promotes Megakaryocytopoiesis In Vitro

Nadine Weich, Anlai Wang, Michael Fitzgerald, +6

Blood

Mice deficient in PKC theta demonstrate impaired<i>in vivo</i>T cell activation and protection from T cell-mediated inflammatory diseases

Karen S. Anderson, Michael Fitzgerald, Michelle DuPont, +9

Autoimmunity

Adaptive Immune SystemT-regulatory CellImmune RegulationImmunologyImmunologic Mechanism +22

Reduction of an Enaminone:  Synthesis of the Diamino Alcohol Core of Ritonavir

Anthony R. Haight, Timothy L. Stuk, M.S. Allen, +9

Organic Process Research & Development

Two-step Reduction SequenceDiamino Alcohol CoreBorane-sulfonate DerivativeOrganic ChemistryStereoselective Synthesis +5