A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Konstantinos Tzelepis, Hiroko Koike-Yusa, Étienne De Braekeleer, +24

Cell Reports

Gene Deletion DataGeneticsAcute Myeloid LeukemiaTherapeutic TargetsGenetic Engineering +7

Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

Dorian Forte, María García‐Fernández, Abel Sánchez‐Aguilera, +21

Cell Metabolism

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo

Paolo Gallipoli, Amy Cook, Susan Rhodes, +6

Blood

Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, +13

Blood

Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition

Mary T. Scott, Koorosh Korfi, Peter Saffrey, +14

Cancer Discovery

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

Faisal Basheer, George Giotopoulos, Eshwar Meduri, +21

The Journal of Experimental Medicine

Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation

Paolo Gallipoli, Francesca Pellicano, Heather Morrison, +6

Blood

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia

George Giotopoulos, W-I Chan, Sarah J. Horton, +10

Oncogene

Hematological MalignancyChromatinP300 Facilitate LeukemogenesisEpigenetic Regulators CbpAcute Myeloid Leukemia +9

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Konstantinos Tzelepis, Étienne De Braekeleer, Demetrios Aspris, +32

Nature Communications

C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i> -Mutant Leukemia

Marie Sabatier, Rudy Birsen, Laura Lauture, +54

Cancer Discovery