Discovery and Characterization of a Second Mammalian Thiol Dioxygenase, Cysteamine Dioxygenase

John E. Dominy, C.R. Simmons, Lawrence L. Hirschberger, +3

Journal of Biological Chemistry

Chemical BiologyAldo-keto ReductaseAldehyde DehydrogenaseBiochemistryCysteamine Oxidation +13

Zika virus productively infects primary human placenta-specific macrophages

Kellie A. Jurado, Michael K. Simoni, Zhonghua Tang, +8

JCI Insight

Maternal ImmunizationFetal BrainMedicinePathogenesisViral Pathogenesis +10

TAM Receptors Are Not Required for Zika Virus Infection in Mice

Andrew K. Hastings, Laura J. Yockey, Brett W. Jagger, +10

Cell Reports

Zika virus causes testicular atrophy

Ryuta Uraki, Jesse Hwang, Kellie A. Jurado, +6

Science Advances

Synthesis of Amino Acid Cofactor in Cysteine Dioxygenase Is Regulated by Substrate and Represents a Novel Post-translational Regulation of Activity

John E. Dominy, Jesse Hwang, S. Guo, +2

Journal of Biological Chemistry

Cofactor FormationAldo-keto ReductaseMolecular BiologyChemical BiologyRedox Biology +16

Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase

Sarah L. Grady, Jesse Hwang, Livia Vastag, +2

Journal of Virology

Viral ReplicationInfection Activates PolyHsv-1 InfectionMolecular VirologyBiochemistry +12

<i>Aedes aegypti</i> NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils

Andrew K. Hastings, Ryuta Uraki, Hallie Gaitsch, +10

Journal of Virology

Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells

John E. Dominy, Jesse Hwang, Martha H. Stipanuk

American Journal of Physiology-Endocrinology and Metabolism

Lipid PeroxidationCysteine AvailabilityExtracellular CysteineRedox BiologyOxidative Stress +18

Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice

Ryuta Uraki, Kellie A. Jurado, Jesse Hwang, +4

The Journal of Infectious Diseases

FertilityReproductive HealthImmunologyMature SpermReproductive Biology +16

Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia

Andrew K. Hastings, Katherine Hastings, Ryuta Uraki, +5

iScience