Accumulation of Natural Killer T Cells in Progressive Nonalcoholic Fatty Liver Disease

Wing‐Kin Syn, Ye Htun Oo, Thiago A. Pereira, +11

Hepatology

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

Wing‐Kin Syn, Steve S. Choi, Evaggelia Liaskou, +20

Hepatology

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

Wing‐Kin Syn, Kolade M. Agboola, Marzena Swiderska, +15

Gut

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

George Philips, Isaac S. Chan, Marzena Swiderska, +15

PLoS ONE

Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension

Guadalupe García–Tsao, Jaime Bosch, Zeid Kayali, +71

Journal of Hepatology

Severe Portal HypertensionHepatologyLiver PhysiologyGastroenterologyPlacebo-controlled Trial +6

Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation

Guanhua Xie, Steve S. Choi, Wing‐Kin Syn, +6

Gut

Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy

Marzena Swiderska‐Syn, Wing‐Kin Syn, Guomin Xie, +7

Gut

Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma

Isaac S. Chan, Cynthia D. Guy, Yuping Chen, +12

Cancer Research

Human Hcc SamplesSignaling PathwayHepatologyTumor MicroenvironmentOncogenic Agent +13

Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis

Jason D. Coombes, Steve S. Choi, Marzena Swiderska‐Syn, +20

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

InflammationFibrosisLiver PhysiologyPathologyChronic Inflammation +5

Proteomic screening of plasma identifies potential noninvasive biomarkers associated with significant/advanced fibrosis in patients with nonalcoholic fatty liver disease

Wei Hou, Michael G. Janech, Philip M. Sobolesky, +4

Bioscience Reports

ImmunologyPathologyFatty Liver DiseaseLiver StiffnessProgenesis Qi +21