Biased allosteric modulation at the <scp>CaS</scp> receptor engendered by structurally diverse calcimimetics

Anne Cook, Shailesh N. Mistry, Karen J. Gregory, +6

British Journal of Pharmacology

Two-Pronged Attack: Dual Inhibition of <i>Plasmodium falciparum</i> M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors

Shailesh N. Mistry, Nyssa Drinkwater, Chiara Ruggeri, +8

Journal of Medicinal Chemistry

Bioorganic ChemistryAntiparasitic AgentMalariaPlasmodium Falciparum AminopeptidasesChemical Biology +17

Synthesis and Pharmacological Profiling of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) as Allosteric Modulators of the M₁ Muscarinic Receptor

Shailesh N. Mistry, Céline Valant, Patrick M. Sexton, +3

Journal of Medicinal Chemistry

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

Nyssa Drinkwater, Natalie B. Vinh, Shailesh N. Mistry, +10

European Journal of Medicinal Chemistry

Potent Dual InhibitorsS1 Pocket InteractionsDrug TargetBiochemistryAntiparasitic Agent +9

Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor

Alaa Abdul‐Ridha, Laura López, Peter Keov, +6

Journal of Biological Chemistry

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor

Alaa Abdul‐Ridha, J. Robert Lane, Shailesh N. Mistry, +5

Journal of Biological Chemistry

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D ₂ Receptor Through Fragmentation of a Bitopic Ligand

Shailesh N. Mistry, Jeremy Shonberg, Christopher J. Draper-Joyce, +7

Journal of Medicinal Chemistry

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Fadi Soukarieh, Ruiling Liu, Manuel Romero, +19

Frontiers in Chemistry

Synthesis and Characterization of High-Affinity 4,4-Difluoro-4-bora-3a,4a-diaza-<i>s</i>-indacene-Labeled Fluorescent Ligands for Human β-Adrenoceptors

Jillian G. Baker, Luke A. Adams, Karolina Salchow, +4

Journal of Medicinal Chemistry

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

Alessandro Paiardini, Rebecca S. Bamert, Komagal Kannan-Sivaraman, +4

PLoS ONE

Molecular DockingMalaria BoxBiochemistryAntiparasitic AgentMetalloprotein +12