Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury

Riccardo Bertini, Marcello Allegretti, Cinzia Bizzarri, +27

Proceedings of the National Academy of Sciences

Unique ModeImmunologyPharmacotherapyCellular PhysiologyInflammation +18

Design of Noncompetitive Interleukin-8 Inhibitors Acting on CXCR1 and CXCR2

Alessio Moriconi, Maria Candida Cesta, Maria Neve Cervellera, +12

Journal of Medicinal Chemistry

InflammationCytokineDrug TargetAnti-inflammatoryDual Allosteric Cxcr1 +12

Neutrophils recruited by <scp>CXCR1/2</scp> signalling mediate post‐incisional pain

Eleonora U Carreira, Vanessa Carregaro, Mauro Martins Teixeira, +6

European Journal of Pain

Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief

Alessio Moriconi, Thiago M. Cunha, Guilherme R. Souza, +18

Proceedings of the National Academy of Sciences

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non‐competitive allosteric inhibitor

Riccardo Bertini, AR Beccari, Barbara Cavalieri, +11

British Journal of Pharmacology

QSAR Modeling and Data Mining Link Torsades de Pointes Risk to the Interplay of Extent of Metabolism, Active Transport, and hERG Liability

Fabio Broccatelli, Raimund Mannhold, Alessio Moriconi, +2

Molecular Pharmaceutics

Qsar ModelingSystems PharmacologyMedicinal ChemistryHerg InhibitionBioanalysis +19

Predicting Human Serum Albumin Affinity of Interleukin-8 (CXCL8) Inhibitors by 3D-QSPR Approach

Loretta Aureli, Gabriele Cruciani, Maria Candida Cesta, +3

Journal of Medicinal Chemistry

Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors

Valeria La Pietra, Stefania Sartini, Lorenzo Botta, +12

European Journal of Medicinal Chemistry

MedicineThyroid DiseasePharmacologyPharmacological ActivityNovel Ret Inhibitors +7

Exploring the activation mechanism of TRPM8 channel by targeted MD simulations

Alessandro Pedretti, Alessandra Labozzetta, Matteo Lo Monte, +3

Biochemical and Biophysical Research Communications

Signal TransductionNatural SciencesTargeted Md SimulationsMolecular BiologyIon Channels +6

Results of the Anatomic Cementless Prosthesis With Different Types of Hydroxyapatite Coating

F.S. Santori, S Ghera, Alessio Moriconi, +1

Orthopedics