Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury

Riccardo Bertini, Marcello Allegretti, Cinzia Bizzarri, +27

Proceedings of the National Academy of Sciences

Unique ModeImmunologyPharmacotherapyCellular PhysiologyInflammation +18

Poly(ADP-ribose) Polymerase Is a B-MYB Coactivator

Maria Neve Cervellera, Arturo Sala

Journal of Biological Chemistry

Direct Transactivation of the Anti-apoptotic Gene Apolipoprotein J (Clusterin) by B-MYB

Maria Neve Cervellera, Giuseppe Raschellà, Giorgia Santilli, +6

Journal of Biological Chemistry

Inhibition of interleukin-8 (CXCL8/IL-8) responses by repertaxin, a new inhibitor of the chemokine receptors CXCR1 and CXCR2

Federica Casilli, Andrea Bianchini, Isabelle Gloaguen, +12

Biochemical Pharmacology

InflammationCytokineChemokine BiologyMedicineNew Inhibitor +11

Design of Noncompetitive Interleukin-8 Inhibitors Acting on CXCR1 and CXCR2

Alessio Moriconi, Maria Candida Cesta, Maria Neve Cervellera, +12

Journal of Medicinal Chemistry

InflammationCytokineDrug TargetAnti-inflammatoryDual Allosteric Cxcr1 +12

Key role of proline‐rich tyrosine kinase 2 in interleukin‐8 (CXCL8/IL‐8)‐mediated human neutrophil chemotaxis

Vito Di Cioccio, Raffaele Strippoli, Cinzia Bizzarri, +10

Immunology

Key RoleLung InflammationInnate Immune SystemImmunologyImmune Regulation +20

Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs).

Laura Brandolini, Marcello Allegretti, Valério Berdini, +7

PubMed

Bioorganic ChemistryScmc Tioether GroupLipid PeroxidationImmunologyChemical Biology +19

B-MYB transactivates its own promoter through SP1-binding sites

Arturo Sala, B. Saitta, Pasquale De Luca, +5

Oncogene

Transcriptional RegulationSignal TransductionProtein ExpressionGene RegulationGene Expression +4

PARP co-activates B-MYB through enhanced phosphorylation at cyclin/cdk2 sites

Giorgia Santilli, Maria Neve Cervellera, Teresa K. Johnson, +3

Oncogene

Signal TransductionParp Co-activates B-mybSignaling PathwayCellular BiochemistryMedicine +4

Pharmacological Inhibition of Interleukin-8 (CXCL8) as a New Approach for the Prevention and Treatment of Several Human Diseases

Cinzia Bizzarri, Marcello Allegretti, Rosa Di Bitondo, +3

Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

ImmunologyCxcl8-induced Pmn ChemotaxisPharmacotherapyPharmacological InhibitionImmunotherapy +15