Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non‐competitive allosteric inhibitor - Concepedia

Concepedia

Publication | Open Access

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non‐competitive allosteric inhibitor

DOI Full Paper Access

72

Citations

55

References

2011

Year

Riccardo Bertini, AR Beccari, Barbara Cavalieri, Alessio Moriconi, Cinzia Bizzarri, Paola Di Benedetto, Claudia Di Giacinto, Isabelle Gloaguen, Emanuela Galliera, MC Cesta,

British Journal of Pharmacology

Abstract

DF 2156A is a non-competitive allosteric inhibitor of both IL-8 receptors CXCR1 and CXCR2. It prevented experimental angiogenesis and hepatic I/R injury in vivo and, therefore, has therapeutic potential for acute and chronic inflammatory diseases.

References

	Year	Citations

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