Howard E. Morton

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-<i>t</i>-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

John W. Gillard, A W Ford‐Hutchinson, Chi-Chung Chan et al. · Canadian Journal of Physiology and Pharmacology · 1989 · 328 citations

Medicine, Biochemistry, Pharmacology +14

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

Carol A. Rouzer, A. W. Ford‐Hutchinson, Howard E. Morton et al. · Journal of Biological Chemistry · 1990 · 317 citations · Full text

Life Sciences, Cell Biology, Pharmacology +13

Development of a Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes for the Synthesis of Endothelin-A Antagonist <b>ABT-546</b>. Scope, Mechanism, and Further Application to the Synthesis of the Antidepressant Rolipram

David M. Barnes, Jianguo Ji, Michael G. Fickes et al. · Journal of the American Chemical Society · 2002 · 209 citations

Pharmacy, Chemistry, Medicinal Chemistry +12

Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes

Jianguo Ji, David M. Barnes, Ji Zhang et al. · Journal of the American Chemical Society · 1999 · 152 citations

Natural Sciences, Chemistry, Biocatalysis +9

Dimethylboron bromide and diphenylboron bromide: cleavage of acetals and ketals

Yvan Guindon, Christiane Yoakim, Howard E. Morton · The Journal of Organic Chemistry · 1984 · 152 citations

Natural Sciences, Chemistry, Analytical Chemistry +4