A new antibiotic selectively kills Gram-negative pathogens

Yu Imai, Kirsten J. Meyer, Akira Iinishi, +25

Nature

AntibioticsGram-negative PathogensAntibacterial AgentAntimicrobial TherapyMicrobiology +4

The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase

Hundeep Kaur, Roman P. Jakob, Jan K. Marzinek, +9

Nature

Antimicrobial Drug DiscoveryAntimicrobial SusceptibilityAntibioticsBiochemistryOuter Membrane Insertase +8

Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp

Yu Imai, Seizo Sato, Yukinori Tanaka, +2

Applied and Environmental Microbiology

Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis

Yu Imai, Glenn Hauk, Jeffrey Quigley, +13

Nature Chemical Biology

Medical MicrobiologyPulmonary TuberculosisHealth SciencesTuberculosis PreventionMycobacterium Tuberculosis +8

A selective antibiotic for Lyme disease

Nadja Leimer, Xiaoqian Wu, Yu Imai, +25

Cell

Antimicrobial StewardshipAntibioticsSelective AntibioticMicrobiologyInfection Control +4

A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP

Negar Shahsavari, Boyuan Wang, Yu Imai, +12

mBio

Silent OperonMolecular BiologySecondary MetabolitesChemical BiologyAntibiotic Resistance +20

Development of the ability to produce secondary metabolites in Streptomyces through the acquisition of erythromycin resistance

Yu Imai, Tatsuya Fujiwara, Kozo Ochi, +1

The Journal of Antibiotics

Secondary MetabolismBiosynthesisAntibioticsBiochemistryMedicine +10

A possible mechanism for lincomycin induction of secondary metabolism in Streptomyces coelicolor A3(2)

Misaki Ishizuka, Yu Imai, Keiichiro Mukai, +4

Antonie van Leeuwenhoek

Secondary MetabolismStreptomyces Coelicolor A3BiosynthesisBiochemistryNatural Sciences +9

A putative mechanism underlying secondary metabolite overproduction by Streptomyces strains with a 23S rRNA mutation conferring erythromycin resistance

Kanata Hoshino, Yu Imai, Keiichiro Mukai, +3

Applied Microbiology and Biotechnology

Secondary MetabolismBiosynthesisAntimicrobial Resistance GeneHealth SciencesAntibiotics +11

Transport of fatty acid is obligatory coupled with H+ entry in spheroplasts of Escherichia coli K12.

K Kameda, Suzuki Lk, Yu Imai

PubMed

BacteriologyMicrobial PhysiologyH+ EntryIncubation MixtureBioenergetics +14