BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Annette B. Vogel, Isis Kanevsky, Ye Che, +71

Nature

VaccinationBnt162b VaccinesVaccine DevelopmentVaccine TargetImmunology +2

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

Mark E. Flanagan, J. A. Abramite, Dennis P. Anderson, +22

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetThiol-reactive Covalent InhibitorsChemistryChemical Biology +15

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2<i>S</i>,5<i>R</i>)-5-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Atli Thorarensen, Martin E. Dowty, Mary Ellen Banker, +24

Journal of Medicinal Chemistry

Specific InhibitorDrug TargetPharmacotherapyChemical BiologyPharmaceutical Chemistry +23

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

Annette B. Vogel, Isis Kanevsky, Ye Che, +58

VaccinationVaccine DevelopmentPrevents Lung InfectionVaccine ResearchImmunology +13

Thermodynamic analysis of water molecules at the surface of proteins and applications to binding site prediction and characterization

Thijs Beuming, Ye Che, Robert Abel, +3

Proteins Structure Function and Bioinformatics

Hydration Site EnergeticsProtein ChemistryThermodynamic AnalysisBiochemistryBiomolecular Structure Prediction +11

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

David Jonathan Wasilko, Z.L. Johnson, Mark Ammirati, +4

Nature Communications

Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

James Schiemer, Reto Horst, Yilin Meng, +13

Nature Chemical Biology

Protein ChemistryBiochemistryBiomolecular Structure PredictionProtein FoldingNatural Sciences +9

Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

Yuhang Liu, Kyle P. Heim, Ye Che, +5

Science Advances

Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections

Justin I. Montgomery, Matthew F. Brown, Usa Reilly, +34

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyNew SeriesAntimicrobial ChemotherapyPharmaceutical Chemistry +17

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

Matthew F. Brown, Usa Reilly, J. A. Abramite, +33

Journal of Medicinal Chemistry